| Test code: | 4620 |
| Type of disorder: | Paraneoplastic and Other Antibody Disorders of the CNS |
| Disease(s) tested for: | Paraneoplastic Neurological Syndrome |
| Tests included: | CASPR2 Antibody Test GAD65 Neurological Syndrome Antibody Test Ganglionic AChR Antibody Test LGI1 Antibody Test NMDA Receptor (NR1-subunit) Autoantibody Test Recombx® Amphiphysin Autoantibody Test Recombx® CAR (Anti-Recoverin) Autoantibody Test Recombx® CV2 Autoantibody Test Recombx® Hu Autoantibody Test Recombx® MaTa Autoantibody Test Recombx® Ri Autoantibody Test Recombx® Yo Autoantibody Test Recombx® Zic4 Autoantibody Test VGCC Type P/Q Autoantibody Test (LEMS) VGKC Antibody Test |
| Clinical Significance: | Anti-Hu, anti-CV2, anti-Yo, anti-Ri, anti-CAR, anti-Ma, anti-Ta, anti-Zic4 antibodies, anti-voltage gated calcium channels (VGCC), anti-P/Q type and voltage gated potassium channels (VGKC), anti- Ganglionic AChR, anti-Amphiphysin, anti-NMDA receptor (NR1-subunit), anti-LGI1, anti-CASPR2, and anti-GAD65 are found in patients with the acute or subacute onset of limbic encephalitis, brainstem encephalitis, focal cortical encephalitis, myelitis, cerebellar degeneration, opsoclonus/myoclonus, retinopathy, sensory neuropathy, autonomic dysfunction, Stiff Person Syndrome and/or Lambert-Eaton Myasthenic Syndrome. This semi-quantitative assay may be useful in monitoring therapeutic responses in select cases. |
| Methodology: | Automated Nanoliter Scale Immunoassay , ELISA , Radioimmunoassay , Immunofluorescence Assay (IFA) |
| Reference Range: | Negative < or = 120; Borderline 121-200; Positive >200 |
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
| CPT: | 86255(3), 86341(1), 83519(2), 86596(1), 83520(8) |
Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.
| Specimen Type: | Serum |
| Specimen Stability: | Room temperature: 72 hours, Refrigerated: 21 days, Frozen: 28 days, |
| Specimen Requirements: | 2 mL (0.5 mL minimum) serum in a Red-top tube or Serum Separator Tube (SST) |
| Instructions: | Serum must be separated from whole blood within 48 hours of collection. |
| Transport Temperature: | Refrigerated |
| Set-up/Analytic Time: | 7-10 days |
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