| Test code: | 4686 |
| Type of disorder: | Paraneoplastic and Other Antibody Disorders of the CNS |
| Disease(s) tested for: | Paraneoplastic Neurological Syndrome |
| Profiles that contain this test: | NeoCerebellar Degeneration Paraneoplastic Profile with Recombx® NeoComplete Paraneoplastic Evaluation with Recombx® Paraneoplastic Autoantibody Evaluation with Recombx®, CSF Paraneoplastic Neurological Syndromes Evaluation with Recombx®, Initial Assessment |
| Clinical Significance: | Purkinje cell (Yo) antibody is mainly found in patients with paraneoplastic cerebellar degeneration and is associated with breast, ovarian, and other gynecologic cancers. Some patients with ovarian cancer have low titers of Yo antibodies in the absence of cerebellar degeneration. This semi-quantitative assay may be useful in monitoring therapeutic responses in select cases. |
| Methodology: | Automated Nanoliter Scale Immunoassay |
| Reference Range: | Serum <1:200; CSF <1:1 |
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
| CPT: | 83520 |
Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.
| Specimen Type: | Serum |
| Specimen Stability: | Room temperature: 72 hours, Refrigerated: 28 days, Frozen: 28 days, |
| Specimen Requirements: | 2 mL (0.5 mL minimum) serum in a Red-top tube or Serum Separator Tube (SST) |
| Instructions: | Serum must be separated from whole blood within 48 hours of collection. |
| Alternate Specimen Type: | Cerebrospinal Fluid (CSF) |
| Alternate Specimen Stability: | Room temperature: 72 hours, Refrigerated: 28 days, Frozen: 28 days, |
| Alternate Specimen Requirements: | 2 mL (0.5 mL minimum) CSF collected in a sterile leak-proof container |
| Transport Temperature: | Refrigerated |
| Set-up/Analytic Time: | 3-5 days |
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