| Test code: | 178 |
| Type of disorder: | Dementia |
| Disease(s) tested for: | Alzheimer's Disease |
| Tests included: | ADmark® ApoE Genotype Analysis and Interpretation (Symptomatic) ADmark® Phospho-Tau/Total-Tau/A Beta42,Analysis and Interp,CSF(Symptomatic) |
| Informed Consent Required: | This test requires physician attestation that patient consent has been received |
| Special Notes: | Athena does not perform ApoE testing for individuals under the age of 18. Pre-test and post-test genetic counseling is strongly recommended. |
| Clinical Significance: | Detection of ApoE2, E3, E4 alleles and levels of Phosphorylated-Tau protein, Total-Tau protein, and Ab42 |
| Methodology: | ELISA , Restriction Fragment Length Polymorphism (RFLP) |
| Reference Range: | Correlation of levels of markers of Phosphorylated-Tau, Total-Tau, and Ab42, Presence of ApoE2, E3, E4 alleles |
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
| CPT: | 81401(1), 83520(3) |
Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.
| Specimen Type: | Cerebrospinal fluid (CSF) and Whole blood |
| Specimen Stability: | CSF- Room temperature: 72 hours, Refrigerated: 21 days, Frozen: 4 months; Whole blood- Room temperature: 10 days, Refrigerated: 10 days, Frozen: Unacceptable, |
| Specimen Requirements: | CSF: 2 mL (0.5 mL minimum); Whole blood: 8 mL (6 mL minimum) |
| Instructions: | CSF: Polypropylene Transfer Tube and Whole blood: Lavender top (EDTA) CSF: Tubes other than polypropylene are not acceptable. CSF: Must be shipped on a cold pack or frozen. Whole blood: Ship room temperature or refrigerated |
| Transport Temperature: | Frozen |
| Set-up/Analytic Time: | 14-21 days |
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