| Clinical Significance: | Detects anti-LRP4 (low density lipoprotein receptor-related protein 4) in the sera of patients with Myasthenia Gravis (MG). The LRP4 protein activates MuSK kinase activity and promotes the clustering of AChR and their stabilization at the NMJ. Anti-LRP4 antibodies are found in approximately 9.2% (range 2% to 50%) of MG patients who are negative for both anti-AChR and anti-MuSK. |
| Methodology: |
Immunofluorescence Assay (IFA)
|
| Reference Range: | See Laboratory Report |
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form.
| Specimen Type: | Serum |
| Specimen Stability: |
Room temperature: 72 hours, Refrigerated: 25 days, Frozen: 25 days, |
| Specimen Requirements: |
2 mL (0.5 mL minimum) serum in a Red-top tube or Serum Separator Tube (SST) |
| Transport Temperature: | Refrigerated |
| Set-up/Analytic Time: | 7-14 days |
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